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Loss of Y-chromosome does not correlate with age at onset of head and neck carcinoma: a case-control study BJMBR
Silva Veiga,L.C.; Bérgamo,N.A.; Reis,P.P.; Kowalski,L.P.; Rogatto,S.R..
Loss of Y-chromosome has been correlated with older age in males. Furthermore, current evidence indicates that Y-chromosome loss also occurs in several human tumors, including head and neck carcinomas. However, the association between Y nullisomy and the occurrence of neoplasias in elderly men has not been well established. In the present study, the association between Y-chromosome loss and head and neck carcinomas was evaluated by comparison to cells from peripheral blood lymphocytes and normal mucosa of cancer-free individuals matched for age using dual-color fluorescence in situ hybridization. Twenty-one patients ranging in age from 28 to 68 years were divided into five-year groups for comparison with 16 cancer-free individuals matched for age. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fluorescence in situ hybridization; Y-chromosome; Chromosomal abnormalities; Head and neck cancer.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200013
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