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| Fu, Z.; Zhou, M.; Zhang, G.; Ren, G.. |
| Our previous studies indicated that recombinant rabies viruses expressing chemokines and cytokines (including GM-CSF) could enhance the immunogenicity by inducing innate immunity and recruiting/activating dendritic cells and B cells. In this study, bacterial flagellin was cloned into the rabies virus genome and recombinant virus rLBNSE-Flic was rescued. To compare the immunogenicity of rLBNSEFlic with recombinant virus expressing GM-CSF (rLBNSE-GMCSF), mice were immunized with each of these recombinant rabies viruses by i.m. or the oral route. The parental virus (rLBNSE) without expression of any foreign molecules was included for comparison. The i.m.-immunized mice were bled at three weeks after the immunization for the measurement of virus neutralizing... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/229 |
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