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Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method BJPS
Resende,Marina Ferrara de; Lino,Cleudiomar Inácio; Souza-Fagundes,Elaine Maria de; Rettore,João Vitor Paes; Oliveira,Renata Barbosa de; Labanca,Renata Adriana.
Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oxidative stress; Diabetes mellitus; Curcumin; Thiazole derivatives; Dietary supplement.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100509
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