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	Provedor de dados BJMBR (3) Autor Guimarães,F. (3) Rettori,O. (3) Vieira-Matos,A.N. (3) Cavalcanti,T.C. (2) Fernandes,G.A. (1) Gregorini,C.C. (1) Vido,A.A. (1) Mais... Palavra-chave Walker 256 tumor (3) Cancer anemia (1) Cancer immunity (1) Hemolytic component (1) Multifocal tumor inoculation (1) Na+ retention (1) Osmotic fragility (1) Plasma fractions (1) RBC osmotic fragility (1) Secondary diuretic response (1) Septal area lesion (1) Systemic effects (1) Temporary anemia (1) Tumor regressive variant (1) Tumor systemic effects (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2003 (1) 2000 (1) 1999 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Changes in red blood cell osmotic fragility induced by total plasma and plasma fractions obtained from rats bearing progressive and regressive variants of the Walker 256 tumor BJMBR Cavalcanti,T.C.; Gregorini,C.C.; Guimarães,F.; Rettori,O.; Vieira-Matos,A.N.. Two variants (A and B) of the widely employed Walker 256 rat tumor cells are known. When inoculated sc, the A variant produces solid, invasive, highly metastasizing tumors that cause severe systemic effects and death. We have obtained a regressive variant (AR) whose sc growth is slower, resulting in 70-80% regression followed by development of immunity against A and AR variants. Simultaneously with the beginning of tumor regression, a temporary anemia developed (~8 days duration), accompanied by marked splenomegaly (~300%) and changes in red blood cell osmotic fragility, with mean corpuscular fragility increasing from 4.1 to 6.5 g/l NaCl. The possibility was raised that plasma factors associated with the immune response induced these changes. In the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Plasma fractions; Temporary anemia; RBC osmotic fragility; Tumor regressive variant; Cancer immunity; Walker 256 tumor. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700009 The hemolytic component of cancer anemia: effects of osmotic and metabolic stress on the erythrocytes of rats bearing multifocal inoculations of the Walker 256 tumor BJMBR Vido,A.A.; Cavalcanti,T.C.; Guimarães,F.; Vieira-Matos,A.N.; Rettori,O.. Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal complications of the illness limit studies of the hemolytic component. A multifocal model of tumor growth was used here to simulate the terminal metastatic dissemination stage (several simultaneous inoculations of Walker 256 cells). The hemolytic component of anemia began 3-4 days after inoculation in 100% of the rats and progressed rapidly thereafter: Hb levels dropped from 14.9 ± 0.02 to 8.7 ± 0.06 from days 7 to 11 (~5 times the physiologically normal rate in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemolytic component; Cancer anemia; Osmotic fragility; Systemic effects; Walker 256 tumor. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700012 The influence of septal lesions on sodium and water retention induced by Walker 256 tumor BJMBR Guimarães,F.; Rettori,O.; Vieira-Matos,A.N.; Fernandes,G.A.. In the course of studies on the effects of septal area lesions on neuroimmunomodulation and Walker 256 tumor development, it was observed that tumor-induced sodium and water retention was less marked in lesioned than in non-lesioned rats. In the present study possible mechanisms involved in this phenomenon were investigated. The experiments were performed in septal-lesioned (LW; N = 15) and sham-operated (SW; N = 7) 8-week-old male Wistar rats, which received multifocal simultaneous subcutaneous (sc) inoculations of Walker 256 tumor cells about 30 days after the stereotaxic surgery. Control groups (no tumor, sham-operated food-restricted (SFR), N = 7) and lesioned food-restricted (LFR, N = 10) were subjected to a feeding pattern similar to that observed in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Na+ retention; Secondary diuretic response; Tumor systemic effects; Septal area lesion; Multifocal tumor inoculation; Walker 256 tumor. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300010 Registros recuperados: 3 Primeira ... 1 ... Última

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