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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Avadi,MR (1) Eskandari,R (1) Mir Mohammad Sadeghi,A (1) Mohammadpour Dounighi,N (1) Rezayat,M (1) Zolfagharian,H (1) Mais... Palavra-chave Antigen delivery system (1) Chitosan (1) Mesobuthus eupeus (1) Nanoparticle (1) Tripolyphosphate (1) Venom (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Preparation and in vitro characterization of chitosan nanoparticles containing Mesobuthus eupeus scorpion venom as an antigen delivery system J. Venom. Anim. Toxins incl. Trop. Dis. Mohammadpour Dounighi,N; Eskandari,R; Avadi,MR; Zolfagharian,H; Mir Mohammad Sadeghi,A; Rezayat,M. Hydrophilic nanoparticles have been widely investigated in recent years as delivery systems for therapeutic macromolecules such as antigens. In the present study Mesobuthus eupeus venom-loaded chitosan nanoparticles were prepared via ionic gelation of tripolyphosphate (TPP) and chitosan. The optimum encapsulation efficiency (91.1%) and loading capacity (76.3%) were obtained by a chitosan concentration of 2 mg/mL, chitosan-to-TPP mass ratio of 2 and M. eupeus venom concentration of 500 µg/mL. The average nanoparticle size at optimum conditions was determined by Zetasizer (Malvern Instruments, UK). The nanoparticle size was about 370 nm (polydispersity index: 0.429) while the zeta potential was positive. Transmission electron microscope (TEM) imaging showed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoparticle; Chitosan; Tripolyphosphate; Venom; Antigen delivery system; Mesobuthus eupeus. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100006 Registros recuperados: 1 Primeira ... 1 ... Última

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