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Development and application of a portable instrument for drugs analysis in pharmaceutical preparations BJPS
Ribeiro,Paulo Roberto da Silva; Pezza,Helena Redigolo; Pezza,Leonardo; Lima,Liliane Spazzapam; Tubino,Matthieu.
This article describes the application and performance of an inexpensive, simple and portable device for colorimetric quantitative determination of drugs in pharmaceutical preparations. The sensor is a light detector resistor (LDR) incorporated into a black PTFE cell and coupled to a low-cost multimeter (Ohmmeter). Quantitative studies were performed with captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems. Calibration curves were obtained by plotting the electrical resistance of the LDR against the concentration of the colored species in the ranges 1.84 × 10-4 to 1.29 × 10-3mol L-1 and 5.04 × 10-4 to 2.52 × 10-3 mol L-1 for captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems, respectively, exhibiting good coefficients of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Optical sensor/application/colorimetric analysis; Instrumentation/drugs dosage; Drugs/quantitative analysis; Drugs/dosage; Pharmaceutical formulations/quality control.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300699
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Development and validation of a simple spectrophotometric method for the determination of methyldopa in both bulk and marketed dosage formulations BJPS
Ribeiro,Paulo Roberto da Silva; Duarte,Reginária Morais.
A simple, precise, sensitive, rapid, specific and economical spectrophotometric method was developed to determine methyldopa (MTD) content in bulk and pharmaceutical dosage formulations. The proposed method was based on the formation of a colored product from the nitrosation reaction of MTD with sodium nitrite in an acid medium. The resultant nitroso derivative species reacts further with sodium hydroxide and is converted it into a more stable compound. This yellow nitrosation product exhibited an absorption maximum at 430 nm. Beer's Law was obeyed in a concentration range of 6.37 to 82.81 μg mL-1 MTD with an excellent coefficient of determination (R2 = 0.9998). No interference was observed from common excipients in formulations. The results showed the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Methyldopa/spectrophotometric determination; Pharmaceutical formulations/quality control; Spectrophotometry/qualitative analysis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300573
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