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	Provedor de dados 17 (3) Autor Richard Gibbs (3) Debasmita Mandal (2) Delphine M. Saulnier (2) James Versalovic (2) Joseph Petrosino (2) Kevin Riehle (2) Maria A. Diaz (2) Robert J. Shulman (2) Sabeen Raza (2) Susan Lynch (2) Toni-Ann Mistretta (2) Xiang Qin (2) Charles Brunicardi (1) David Dawson (1) Donald Rao (1) Francesco DeMayo (1) John Nemunaitis (1) Kelly Stehling (1) Marie-Claude Gingras (1) Michael Norman (1) Mais... Palavra-chave Genetics & Genomics (3) Bioinformatics (2) Ecology (2) Microbiology (2) Cancer (1) Data Standards (1) Mais... Tipo do documento Marker Paper / Data Plan (2) Manuscript (1) Ano 2011 (1) 2010 (2) País United Kingdom (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1 17 Shi-He Liu; Donald Rao; John Nemunaitis; Neil Senzer; David Dawson; Marie-Claude Gingras; Zhaohui Wang; Richard Gibbs; Michael Norman; Nancy Templeton; Francesco DeMayo; Kelly Stehling; William Fisher; Charles Brunicardi. Bi-functional shRNA (bi-shRNA), a novel RNA interference (RNAi) effector platform targeting PDX-1 utilizing a systemic DOTAP-Cholesterol delivery vehicle, was studied in three mouse models of progressive pancreatic neoplasia. Species-specific bi-functional PDX-1 shRNA (bi-shRNAPDX-1) lipoplexes inhibited insulin expression and secretion while also substantially inhibiting proliferation of mouse and human cell lines via disruption of cell cycle proteins in vitro. Three cycles of either bi-shRNA<sup>mousePDX-1</sup> or shRNA<sup>mousePDX-1</sup> lipoplexes administered intravenously prevented death from hyperinsulinemia and hypoglycemia in a lethal insulinoma mouse model. Three cycles of... Tipo: Manuscript Palavras-chave: Cancer; Genetics & Genomics. Ano: 2011 URL: http://precedings.nature.com/documents/6047/version/1 The Human Microbiome and Recurrent Abdominal Pain in Children 17 James Versalovic; Robert J. Shulman; Kevin Riehle; Delphine M. Saulnier; Toni-Ann Mistretta; Maria A. Diaz; Sabeen Raza; Debasmita Mandal; Xiang Qin; Susan Lynch; Joseph Petrosino; Richard Gibbs. This project explores the nature of the human intestinal microbiome in healthy children and children with recurrent abdominal pain. The overall goal is to obtain a robust knowledge base of the intestinal microbiome in children without evidence of pain or gastrointestinal disease and in those with recurrent abdominal pain (functional abdominal pain (FAP) and FAP associated with changes in bowel habits, i.e., irritable bowel syndrome or IBS). Specific aims include: 1. Characterize the composition of the gut microbiome in healthy children by DNA sequencing. 2. Determine the presence of disease-specific organism signatures of variable gut microbiomes in children with recurrent abdominal pain. 3. Perform functional gut metagenomics by evaluation of whole... Tipo: Marker Paper / Data Plan Palavras-chave: Ecology; Genetics & Genomics; Microbiology; Bioinformatics. Ano: 2010 URL: http://precedings.nature.com/documents/5228/version/1 The Human Microbiome and Recurrent Abdominal Pain in Children 17 James Versalovic; Robert J. Shulman; Kevin Riehle; Delphine M. Saulnier; Toni-Ann Mistretta; Maria A. Diaz; Sabeen Raza; Debasmita Mandal; Xiang Qin; Susan Lynch; Joseph Petrosino; Richard Gibbs. This project explores the nature of the human intestinal microbiome in healthy children and children with recurrent abdominal pain. The overall goal is to obtain a robust knowledge base of the intestinal microbiome in children without evidence of pain or gastrointestinal disease and in those with recurrent abdominal pain (functional abdominal pain (FAP) and FAP associated with changes in bowel habits, i.e., irritable bowel syndrome or IBS). Specific aims include: 1. Characterize the composition of the gut microbiome in healthy children by DNA sequencing. 2. Determine the presence of disease-specific organism signatures of variable gut microbiomes in children with recurrent abdominal pain. 3. Perform functional gut metagenomics by evaluation of whole... Tipo: Marker Paper / Data Plan Palavras-chave: Ecology; Genetics & Genomics; Microbiology; Bioinformatics; Data Standards. Ano: 2010 URL: http://precedings.nature.com/documents/5228/version/2 Registros recuperados: 3 Primeira ... 1 ... Última

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