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Prednisone raw material characterization and formulation development BJPS
Toehwé,Leonardo Henrique; Prado,Livia Deris; Rocha,Helvécio Vinícius Antunes.
ABSTRACT Solid dosage forms for oral use, particularly tablets, are the most highly used dosage forms in therapy because they are easily administered, have high productivity and relatively low cost and provide a more stable drug to form a semi-solid net. Numerous parameters influence the quality of the final dosage form. In this study, the dissolution profile of 20-mg prednisone tablets bioequivalent to the reference product and three test formulations were evaluated using stability testing. During the study, prednisone tablets and the active pharmaceutical ingredient (API) prednisone from two different manufacturers were characterized with respect to their physical and physicochemical properties. The results showed that the dissolution profiles of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Prednisone/tablets/dissolution; Solubility; Formulation; Stability.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400604
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