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	Provedor de dados BJPS (1) Autor Fuentefria,Alexandre Meneghello (1) Mezzari,Adelina (1) Pippi,Bruna (1) Rocha,Letícia Fernandes da (1) Palavra-chave Cryptococcus neoformans (1) Fluconazole (1) Ibuprofen (1) Itraconazole (1) Synergism (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2020 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans BJPS Rocha,Letícia Fernandes da; Pippi,Bruna; Fuentefria,Alexandre Meneghello; Mezzari,Adelina. The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Ibuprofen; Itraconazole; Fluconazole; Synergism. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100577 Registros recuperados: 1 Primeira ... 1 ... Última

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