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	Provedor de dados BJMBR (3) Autor Rodrigues,A.L.S. (3) Filippin,A. (1) Garcia,R.C. (1) Giacomelli,M.B.O. (1) Goulart,E.C. (1) Kraemer,C.K. (1) Mantovani,M. (1) Martins,A.F. (1) Matteussi,A.S. (1) Mello,C.F. (1) Morsch,V.M. (1) Pereira,C.A.T. (1) Rubin,M.A. (1) Mais... Palavra-chave Lead acetate (2) Delta-aminolevulinate dehydratase (1) Depression (1) Forced swimming test (1) Heavy metal intoxication (1) Lead (1) Negative geotaxis (1) Neurobehavioral development (1) Open-field (1) Postnatal brain growth (1) Rat (1) Teratology (1) Undernutrition (1) Zinc chloride (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Info:eu-repo/semantics/article (1) Ano 2001 (1) 1999 (1) 1998 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Antidepressant-like effect of lead in adult mice BJMBR Mantovani,M.; Matteussi,A.S.; Rodrigues,A.L.S.. It has been reported that lead can cause behavioral impairment by inhibiting the N-methyl-D-aspartate (NMDA) receptor complex. MK-801, a noncompetitive NMDA receptor antagonist, exhibits an antidepressant-like action in the forced swimming test. The purpose of the present study was to determine whether subacute lead exposure in adult male Swiss mice weighing 30-35 g causes an antidepressant-like action in a forced swimming test. Mice were injected intraperitoneally (ip) with 10 mg/kg lead acetate or saline daily for 7 consecutive days. Twenty-four hours after the last treatment, the saline and lead-treated mice received an injection of MK-801 (0.01 mg/kg, ip) or saline and were tested in forced swimming and in open-field tests. Immobility time was... Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead acetate; Forced swimming test; Depression; Open-field. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200017 Effects of lead and/or zinc exposure during the second stage of rapid postnatal brain growth on delta-aminolevulinate dehydratase and negative geotaxis of suckling rats BJMBR Goulart,E.C.; Pereira,C.A.T.; Garcia,R.C.; Giacomelli,M.B.O.; Rodrigues,A.L.S.. Lead has been shown to produce cognitive and motor deficits in young rats that could be mediated, at least in part, by inhibition of the zinc-containing heme biosynthetic enzyme delta-aminolevulinate dehydratase (ALA-D). In the present study we investigated the effects of lead and/or zinc treatment during the second stage of rapid postnatal brain development on brain, kidney and blood ALA-D specific activity, as well as the negative geotaxis behavior of rats. Eight-day-old Wistar rats were injected intraperitoneally with saline, lead acetate (8 mg/kg) and/or zinc chloride (2 mg/kg) daily for five consecutive days. Twenty-four hours after treatment, ALA-D activity was determined in the absence and presence of DL-dithiothreitol (DTT). The negative geotaxis... Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead acetate; Zinc chloride; Delta-aminolevulinate dehydratase; Negative geotaxis; Postnatal brain growth. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600014 Effect of lead acetate on neurobehavioral development of rats BJMBR Mello,C.F.; Kraemer,C.K.; Filippin,A.; Morsch,V.M.; Rodrigues,A.L.S.; Martins,A.F.; Rubin,M.A.. We investigated the effects of lead exposure during the pre- and postnatal period on the neurobehavioral development of female Wistar rats (70-75 days of age, 120-150 g) using a protocol of lead intoxication that does not affect weight gain. Wistar rats were submitted to lead acetate intoxication by giving their dams 1.0 mM lead acetate. Control dams received deionized water. Growth and neuromotor development were assessed by monitoring daily the following parameters in 20 litters: body weight, ear unfolding, incisor eruption, eye opening, righting, palmar grasp, negative geotaxis, cliff avoidance and startle reflex. Spontaneous alternation was assessed on postnatal day 17 using a T maze. The animals' ability to equilibrate on a beaker rim was measured on... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lead; Neurobehavioral development; Undernutrition; Heavy metal intoxication; Teratology; Rat. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700010 Registros recuperados: 3 Primeira ... 1 ... Última

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