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Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice BABT
Rodrigues,Patrik Oening; Becker,Ana Cláudia; Dellagnelo,Viviane Aparecida; Benetti,Cibele Nabhan; Pereira,Eduardo Manoel; Wagner,Theodoro Marcel; Silva,Marcos Antonio Segatto.
The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Solubility; Dexamethasone acetate; Β-cyclodextrin; Bioavailability; Anti-inflammatory activity.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887
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Physicochemical study of CaCO3 from egg shells Ciênc. Tecnol. Aliment.
Murakami,Fabio Seigi; Rodrigues,Patrik Oening; Campos,Célia Maria Teixeira de; Silva,Marcos Antônio Segatto.
Calcium carbonate, a pharmaceutical excipient, is widely used as diluent in solid dosage forms. It is also used as a base for medicinal and dental preparations, a buffering and dissolution aid for dispersible tablets, a food additive and a calcium supplement. Egg shells are a rich source of mineral salts, mainly calcium carbonate, which corresponds to about 94% of the shell. Layer farms produce large amounts of shells, whose final disposal poses a challenge from the environmental standpoint. This work was designed to evaluate the physicochemical and thermal properties of calcium carbonate obtained from egg shells. The findings indicated that calcium carbonate from egg shells can be used as an alternative pharmaceutical excipient.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thermal analysis; X-ray powder diffraction; Egg shells; Calcium carbonate.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612007000300035
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