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Evaluation of resistance acquisition during tuberculosis treatment using whole genome sequencing BJID
Silva Feliciano,Cinara; Rodrigues Plaça,Jessica; Peronni,Kamila; Araújo Silva Jr,Wilson; Roberto Bollela,Valdes.
Abstract Tuberculosis (TB) is still considered a major global public health problem in the world and there is a concern about the worldwide increase of drug-resistance (DR). This paper describes the analysis of three Mycobacterium tuberculosis isolates from a single patient collected over a long treatment period of time. DR was initially investigated through phenotypic testing, followed by line probe assays (LPAs) and whole genome sequencing (WGS). It presents an intriguing situation where a multidrug-resistant (MDR-) TB case was diagnosed and treated based only on late phenotypic drug susceptibility testing of isolate 1. During the treatment, another two isolates were cultivated: isolate 2, nine months after starting MDR-TB treatment; and isolate 3,...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Tuberculosis; Drug resistant tuberculosis; Drug susceptibility tests; Whole genome sequencing.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300012
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