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	Provedor de dados BJMBR (3) Autor Rogatto,S.R. (3) Achatz,M.I. (1) Bérgamo,N.A. (1) Domingues,M.A.C. (1) Fortes,F.P. (1) Kowalski,L.P. (1) Kuasne,H. (1) Marchi,F.A. (1) Miranda,P.M. (1) Reis,P.P. (1) Rosa,F.E. (1) Santos,R.M. (1) Silva Veiga,L.C. (1) Mais... Palavra-chave Breast cancer (1) CISH (1) Chromosomal abnormalities (1) FISH (1) Fluorescence in situ hybridization (1) HER2 (1) Head and neck cancer (1) Immunohistochemistry (1) Li-Fraumeni syndrome (1) Methylation (1) TDG (1) TP53 gene (1) Y-chromosome (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2015 (1) 2013 (1) 2012 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Loss of Y-chromosome does not correlate with age at onset of head and neck carcinoma: a case-control study BJMBR Silva Veiga,L.C.; Bérgamo,N.A.; Reis,P.P.; Kowalski,L.P.; Rogatto,S.R.. Loss of Y-chromosome has been correlated with older age in males. Furthermore, current evidence indicates that Y-chromosome loss also occurs in several human tumors, including head and neck carcinomas. However, the association between Y nullisomy and the occurrence of neoplasias in elderly men has not been well established. In the present study, the association between Y-chromosome loss and head and neck carcinomas was evaluated by comparison to cells from peripheral blood lymphocytes and normal mucosa of cancer-free individuals matched for age using dual-color fluorescence in situ hybridization. Twenty-one patients ranging in age from 28 to 68 years were divided into five-year groups for comparison with 16 cancer-free individuals matched for age. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fluorescence in situ hybridization; Y-chromosome; Chromosomal abnormalities; Head and neck cancer. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200013 DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations BJMBR Fortes,F.P.; Kuasne,H.; Marchi,F.A.; Miranda,P.M.; Rogatto,S.R.; Achatz,M.I.. Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence of cancer and age of disease onset are known to vary, even in patients carrying the same mutation, and several mechanisms such as genetic and epigenetic alterations may be involved in this variability. However, the extent of involvement of such events has not been clarified. It is well established that p53 regulates several pathways, including the thymine DNA glycosylase (TDG) pathway, which regulates the DNA methylation of several genes. This study aimed to identify the DNA methylation pattern of genes potentially related to the TDG... Tipo: Info:eu-repo/semantics/article Palavras-chave: Li-Fraumeni syndrome; TP53 gene; TDG; Methylation. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700610 Chromogenic in situ hybridization compared with other approaches to evaluate HER2/neu status in breast carcinomas BJMBR Rosa,F.E.; Santos,R.M.; Rogatto,S.R.; Domingues,M.A.C.. Human epidermal growth factor receptor 2 (HER2) has been evaluated in breast cancer patients to identify those most likely to benefit from herceptin-targeted therapy. HER2 amplification, detected in 20-30% of invasive breast tumors, is associated with reduced survival and metastasis. The most frequently used technique for evaluating HER2 protein status as a routine procedure is immunohistochemistry (IHC). HER2 copy number alterations have also been evaluated by fluorescence in situ hybridization (FISH) in moderate immunoexpression (IHC 2+) cases. An alternative procedure to evaluate gene amplification is chromogenic in situhybridization (CISH), which has some advantages over FISH, including the correlation between HER2 status and morphological features.... Tipo: Info:eu-repo/semantics/article Palavras-chave: CISH; Breast cancer; HER2; Immunohistochemistry; FISH. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300207 Registros recuperados: 3 Primeira ... 1 ... Última

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