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	Provedor de dados Genet. Mol. Biol. (2) Autor Rogatto,Silvia Regina (2) Barbieri Neto,José (1) Baruffi,Marcelo Razera (1) Engel,Edgard Edward (1) Moraes,Lamartine Correa de (1) Rainho,Cláudia Aparecida (1) Squire,Jeremy Andrew (1) Tone,Luis Gonzaga (1) Mais... Palavra-chave CGH (1) Comparative genomic hybridization (1) Ewing's Sarcoma (1) Osteosarcoma (1) Tipo do documento Info:eu-repo/semantics/article (2) Ano 2003 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization Genet. Mol. Biol. Baruffi,Marcelo Razera; Engel,Edgard Edward; Squire,Jeremy Andrew; Tone,Luis Gonzaga; Rogatto,Silvia Regina. We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies demonstrate the value of molecular cytogenetic methods in the characterization of recurrent genomic alterations in bone tumor tissue. Tipo: Info:eu-repo/semantics/article Palavras-chave: Comparative genomic hybridization; CGH; Osteosarcoma; Ewing's Sarcoma. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200001 Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions Genet. Mol. Biol. Rainho,Cláudia Aparecida; Barbieri Neto,José; Moraes,Lamartine Correa de; Rogatto,Silvia Regina. Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens). Tipo: Info:eu-repo/semantics/article Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100006 Registros recuperados: 2 Primeira ... 1 ... Última

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