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	Provedor de dados BJMBR (1) Autor Domingues,M.A.C. (1) Rogatto,S.R. (1) Rosa,F.E. (1) Santos,R.M. (1) Palavra-chave Breast cancer (1) CISH (1) FISH (1) HER2 (1) Immunohistochemistry (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Chromogenic in situ hybridization compared with other approaches to evaluate HER2/neu status in breast carcinomas BJMBR Rosa,F.E.; Santos,R.M.; Rogatto,S.R.; Domingues,M.A.C.. Human epidermal growth factor receptor 2 (HER2) has been evaluated in breast cancer patients to identify those most likely to benefit from herceptin-targeted therapy. HER2 amplification, detected in 20-30% of invasive breast tumors, is associated with reduced survival and metastasis. The most frequently used technique for evaluating HER2 protein status as a routine procedure is immunohistochemistry (IHC). HER2 copy number alterations have also been evaluated by fluorescence in situ hybridization (FISH) in moderate immunoexpression (IHC 2+) cases. An alternative procedure to evaluate gene amplification is chromogenic in situhybridization (CISH), which has some advantages over FISH, including the correlation between HER2 status and morphological features.... Tipo: Info:eu-repo/semantics/article Palavras-chave: CISH; Breast cancer; HER2; Immunohistochemistry; FISH. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300207 Registros recuperados: 1 Primeira ... 1 ... Última

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