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Neutral space analysis for a Boolean network model of the fission yeast cell cycle network 48
Ruz,Gonzalo A; Timmermann,Tania; Barrera,Javiera; Goles,Eric.
BACKGROUND: Interactions between genes and their products give rise to complex circuits known as gene regulatory networks (GRN) that enable cells to process information and respond to external stimuli. Several important processes for life, depend of an accurate and context-specific regulation of gene expression, such as the cell cycle, which can be analyzed through its GRN, where deregulation can lead to cancer in animals or a directed regulation could be applied for biotechnological processes using yeast. An approach to study the robustness of GRN is through the neutral space. In this paper, we explore the neutral space of a Schizosaccharomyces pombe (fission yeast) cell cycle network through an evolution strategy to generate a neutral graph, composed of...
Tipo: Journal article Palavras-chave: Neutral graph; Boolean networks; Evolution strategy; Fission yeast cell cycle; Attractors.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100058
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Discovering Craniofacial Patterns Using Multivariate Cephalometric Data for Treatment Decision Making in Orthodontics 77
Araya-Díaz,Pamela; Ruz,Gonzalo A; Palomino,Hernán M.
The aim was to find craniofacial morphology patterns in a multivariate cephalometric database using a clustering technique. Cephalometric analysis was performed in a sample of 100 teleradiographs collected from Chilean orthodontic patients. Thirty cephalometric measurements were taken from commonly used analysis. The computed variables were used to perform a clustering analysis with the k-means algorithm to identify patterns of craniofacial morphology. The J48 decision tree was used to analyze each cluster, and the ANOVA test to determine the statistical differences between the clusters. Four clusters were found that had significant differences (P<0.001) in 24 of the 30 variables studied, suggesting that they represent different patterns of craniofacial...
Tipo: Journal article Palavras-chave: Craniofacial patterns; Morphological patterns; Clustering technique; Orthodontics.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300053
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