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	Provedor de dados Biol. Res. (2) Autor SÁNCHEZ,GITTITH (2) CUELLAR,DANIELA (1) GAJARDO,MARTA (1) GONZÁLEZ-MARTIN,GUILLERMO (1) MUGA,MABEL (1) ORTÍZ,SILVIA (1) SOLARI,ALDO (1) VILLAGRA,REBECA (1) WALLACE,ANNE (1) ZULANTAY,INES (1) Mais... Palavra-chave Trypanosoma cruzi (2) Amastigotes (1) Bloodstream forms (1) Clonets (1) Mortality (1) Multilocus enzyme electrophoresis (1) Nanoparticles (1) Nifurtimox (1) Parasitemia (1) Trypomastigotes (1) Mais... Tipo do documento Journal article (2) Ano 2002 (1) 2001 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cytotoxicity and trypanocidal activity of nifurtimox encapsulated in ethylcyanoacrylate nanoparticles Biol. Res. SÁNCHEZ,GITTITH; CUELLAR,DANIELA; ZULANTAY,INES; GAJARDO,MARTA; GONZÁLEZ-MARTIN,GUILLERMO. The aim of the present study was to study the trypanocidal activity of nanoparticles loaded with nifurtimox in comparison with the free drug against Trypanosoma cruzi, responsible for Chagas' disease. Ethylcyanoacrylate nanoparticles acted as the delivery system into cells. As the obligate replicative intracellular form is amastigote, in vitro studies were performed on this form of parasite as well as on cell culture derived trypomastigotes. The fluorescence method used here was very useful as it allowed for the simultaneous study of trypanocide activity and cytotoxicity by determining living or dead parasites within living or dead host cells. According to these results, the greatest trypanocide activity on cell culture-derived trypomastigotes was recorded... Tipo: Journal article Palavras-chave: Nifurtimox; Nanoparticles; Amastigotes; Trypomastigotes; Trypanosoma cruzi. Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100007 Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets Biol. Res. WALLACE,ANNE; ORTÍZ,SILVIA; SÁNCHEZ,GITTITH; VILLAGRA,REBECA; MUGA,MABEL; SOLARI,ALDO. The biological characterization of bloodstream forms of eleven Trypanosoma cruzi cloned stocks, corresponding to two genetically similar clonets (<A HREF="#19">19</A> and <A HREF="#20">20</A>) and one distant clonet (39), according to multilocus enzyme electrophoresis analysis, showed dissimilar parasitemia in an experimental isogenic mouse model. While clonet 39 stocks gave low parasitemias, clonets 19 or 20 stocks gave high parasitemias, independently of the inocula (10² and 10(4) bloodstream forms) used. High parasitemia did not always associate with greater mortality. Statistical studies on mortality using a low inocula showed significantly higher mortality with clonet 39 stocks when compared to clonets 19 or 20 stocks. Finally,... Tipo: Journal article Palavras-chave: Trypanosoma cruzi; Clonets; Parasitemia; Mortality; Bloodstream forms; Multilocus enzyme electrophoresis. Ano: 2001 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200011 Registros recuperados: 2 Primeira ... 1 ... Última

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