| CD5L (CD5 antigen -like) is a secreted glycoprotein that belongs to the SRCR (scavenger receptor cysteine rich) group B family of proteins that regulate leukocyte function. Over expression of human CD5L leads to Kawasaki disease and atherosclerosis. In the quest of designing novel inhibitors against CD5L, homology models for the protein were predicted based on crystal structures of 1BY2, 2OYA and 2OY3 as multiple templates using Modeller 9v9. The CD5L homology models were selected using GA341 score, DOPE score, PROCHECK and ProSA to select the best model. The selected CD5L model was analyzed using CASTp to locate the largest ligand binding pocket. Five known inhibitors of human CD5L were searched for structural analogs from Ligand.Info Meta database. The... |
