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| FUTURO,DÉBORA O.; FERREIRA,PATRICIA G.; NICOLETTI,CAROLINE D.; BORBA-SANTOS,LUANA P.; SILVA,FERNANDO C. DA; ROZENTAL,SONIA; FERREIRA,VITOR FRANCISCO. |
| ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinones; Xanthenes; Lapachol; Lawsone; Candida spp; Disc diffusion method. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301187 |
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| CHIPOLINE,INGRID C.; ALVES,EVELYNE; BRANCO,PAOLA; COSTA-LOTUFO,LETICIA V.; FERREIRA,VITOR F.; SILVA,FERNANDO C. DA. |
| ABSTRACT The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies. Thus, a series of eleven 1,2-naphthoquinones tethered in C2 to 1,2,3-1H-triazoles 9a-k were designed, synthesized and their cytotoxic activity evaluated using HCT-116 (colon adenocarcinoma), MCF-7 (breast adenocarcinoma) and RPE (human nontumor cell line from retinal epithelium). The chemical synthesis was performed from C-3 allylation of lawsone followed by iodocyclization with subsequent nucleophilic displacement with sodium azide and, finally, the 1,3-dipolar cycloaddition catalyzed by Cu(I) with terminal alkynes led to the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Naphthoquinones lawsone 1; 2; 3-triazoles cancer colon adenocarcinoma breast adenocarcinoma. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301027 |
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