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| LÓPEZ,KELVIN S.E.; MARQUES,ANDRÉ M.; MOREIRA,DAVYSON DE L.; VELOZO,LEOSVALDO S.; SUDO,ROBERTO T.; ZAPATA-SUDO,GISELE; GUIMARÃES,ELSIE F.; KAPLAN,MARIA AUXILIADORA C.. |
| ABSTRACT Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as "anestesia" and it is a common habit of chewing leaves and roots of Ottonia species to relief toothache. The purpose of this study is to report our findings on new molecules entities obtained from the roots of Ottonia anisum Spreng, in which local anesthetic activity (sensory blockage) is demonstrated for the first time in vivo guinea pig model. Phytochemical investigation led to the isolation of three... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Piperaceae; Piper; Ottonia; Amides; Anesthetic properties; Sensory blockage. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602229 |
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