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	Provedor de dados Biol. Res. (1) BJM (1) Autor Sajid,Imran (2) Aftab,Usman (1) Hasnain,Shahida (1) Shaaban,Khaled A. (1) Zechel,David L. (1) Palavra-chave 2 (1) 3-triol (1) Indigenous Streptomyces sp. CTF9 (1) Indolyl-3-lactic acid (1) Phenylacetic acid (1) Streptomyces sp KML-2 Antitumor activity Chromomycin SA 1-(1 H-indol-3-yl)-propane-1 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2015 (1) 2011 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antitumor compounds from Streptomyces sp. KML-2, isolated from Khewra salt mines, Pakistan Biol. Res. Aftab,Usman; Zechel,David L.; Sajid,Imran. BACKGROUND: Actinomycetes are gram positive bacteria with high G + C content in their DNA and are capable of producing variety of secondary metabolites. Many of these metabolites possess different biological activities and have the potential to be developed as therapeutic agents. The aim of the present study was to screen actinomycetes inhabiting halophilic environment such as Khewra salt mines present in Pakistan for cytotoxic and antitumor compounds RESULTS: An actiomycetes strain designated as Streptomyces sp. KML-2 was isolated from a saline soil of Khewra salt mines, Pakistan. The strain Streptomyces sp. KML-2 showed 84 % cytotoxic activity against larvae of Artemiasalina. In the screening phase, the strain exhibited significant antitumor activity... Tipo: Journal article Palavras-chave: Streptomyces sp KML-2 Antitumor activity Chromomycin SA 1-(1 H-indol-3-yl)-propane-1; 2; 3-triol. Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100058 Identification, isolation and optimization of antifungal metabolites from the Streptomyces Malachitofuscus ctf9 BJM Sajid,Imran; Shaaban,Khaled A.; Hasnain,Shahida. An indigenous Streptomyces isolate CTF9, exhibiting promising antifungal activity against Mucor miehei and Candida albicans in pre-screening studies, was investigated by cultivation in a 50-L fermenter and by subsequent isolation, purification, and structure elucidation of the active metabolites. Based on the morphological, biochemical, and physiological characterization, as well as the 16S rRNA gene sequence, the isolate CTF9 was identified as Streptomyces malachitofuscus. Using a series of chromatographic techniques, two pure compounds were isolated from the obtained extracts after the fermentation of the isolate CTF9. The isolated compounds were identified as phenylacetic acid and indolyl-3-lactic acid by mass spectrometry (MS) and NMR analysis. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phenylacetic acid; Indolyl-3-lactic acid; Indigenous Streptomyces sp. CTF9. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000200024 Registros recuperados: 2 Primeira ... 1 ... Última

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