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| Ybañez, Rochelle Haidee D.; Leesombun, Arpron; Nishimura, Maki; Matsubara, Ryuma; Kojima, Mikiko; Sakakibara, Hitoshi; Nagamune, Kisaburo; Nishikawa, Yoshifumi. |
| Neospora caninum causes abortion and stillbirth in cattle. Identification of effective drugs against this parasite remains a challenge. Previous studies have suggested that disruption of abscisic acid (ABA)-mediated signaling in apicomplexan parasites such as Toxoplasma gondii offers a new drug target. In this study, the ABA inhibitor, fluridone (FLU), was evaluated for its action against N. caninum. Production of endogenous ABA within N. caninum was confirmed by ultra-performance liquid chromatography-tandem quadruple mass spectrometry. Subsequently, FLU treatment efficacy was assessed using in vitro. Results revealed that FLU inhibited the growth of N. caninum and T. gondii in vitro (IC50 143.1 +/- 43.96 mu M and 330.6 +/- 5238 mu M, respectively).... |
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Palavras-chave: Neospora caninum; Fluridone; Abscisic acid. |
| Ano: 2016 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4491 |
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