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| Sanches,Andréia Cristina Conegero; Correr,Cassyano Januário; Venson,Rafael; Gonçalves,Patrícia Rodrigues; Garcia,Mariana Martins; Piantavini,Mário Sérgio; Pontarolo,Roberto. |
| All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues. We performed a systematic review of the literature and a meta-analysis according to the Cochrane Collaboration methodology. In the absence of clinical studies comparing insulins, we performed a mixed treatment comparison to establish the differences between the active treatments. We included studies published from 1995 to 2010. HbA1c results, episodes of hypoglycemia and nocturnal hypoglycemia data were extracted and analyzed. Thirty-five randomized clinical trials were selected after examining the abstract and a full text review. These studies included 4,206 patients who received... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insulins/meta-analysis; Diabetes mellitus/type 1; Insulin/treatment efficacy; Insulin/safety use. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300011 |
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| Lopes,Gisely Cristiny; Sanches,Andréia Cristina Conegero; Toledo,Cleyton Eduardo Mendes de; Isler,Ana Cristina; Mello,João Carlos Palazzo de. |
| Um método de separação e quantificação por cromatografia líquida de alta eficiência (CLAE) em fase reversa foi desenvolvido usando água (0,05% de TFA):acetonitrila (0,05% de TFA) como fase móvel, em sistema gradiente para a análise dos flavan-3-óis presentes em extrato semipurificado das cascas de Stryphnodendron adstringens, Stryphnodendron polyphyllum e Stryphnodendron obovatum. A CLAE foi realizada com a fração acetato de etila (FAE) sendo submetida à extração em fase sólida (cartucho C18-E) com metanol:água (2:8), filtrada por membrana de porosidade 0,5 μm; a pré-coluna e coluna empregadas foram Phenomenex® Gemini C-18 (5 μm), com esta última mantida a 30 ºC, com vazão de 0,8 mL/min e detecção a 210 nm. Utilizaram-se soluções dos padrões de ácido... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Stryphnodendron adstringens; Stryphnodendron polyphyllum; Stryphnodendron obovatum; Cromatografia líquida de alta eficiência; Taninos/determinação quantitativa; Análise quantitativa. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100017 |
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| Zocoler,Analice Martins Daleffi; Sanches,Andréia Cristina Conegero; Albrecht,Ingrid; Mello,João Carlos Palazzo de. |
| The extract from stem bark of Stryphnodendron obovatum Benth. was chromatographed on a Sephadex® LH-20 column, and yielded nine compounds: gallic acid (GA), p-hydroxybenzoic acid (PHB), gallocatechin (GC), epigallocatechin (EPG), 4'-O-methylgallocatechin (MGC), epigallocatechin-(4β→8)-epigallocatechin (EPEP), epigallocatechin-(4β→8)-gallocatechin (EPGC), robinetinidol-(4α→8)-gallocatechin (ROGC) and robinetinidol-(4β→8)-epigallocatechin (ROEP). Evaluation of the antioxidant capacity in vitro by the methods of DPPH free radical (IC50; μg/mL) and reduction of the phosphomolybdenum complex (RAC) gave the following results, respectively: crude extract 4.52 and 0.8242; ethyl-acetate fraction 4.04 and 0.9537; aqueous fraction 5.58 and 0.9275. The crude extract... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Stryphnodendron obovatum; Antioxidant capacity; Condensed tannins; DPPH free radical; Phosphomolybdenum complex. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300009 |
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