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| Moro,Isabela Jacob; Gondo,Gabrielle Demmany Gualberto Alexandre; Pierri,Elaíse Gonçalves; Pietro,Rosemeire Cristina Linharis Rodrigues; Soares,Christiane Pienna; Sousa,Damião Pergentino de; Santos,André Gonzaga dos. |
| ABSTRACT Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal activity (MIC and MFC) were evaluated against Candida parapsilosis, C. tropicalis, C. krusei and C. albicans and the antibacterial activity (MIC and MBC) against Escherichia coli and Staphylococcus aureus. The cytotoxicity assays were performed with human cancer cell lines HepG-2 and SiHa and the normal strain MRC-5 through... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carvone/antimicrobial activity; Carvone/antifungal activity; Carvone /cytotoxicity; Carvone/chemoprevention. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400602 |
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| Fonseca-Santos,Bruno; Funagoshi,Erica Emi; Oliveira,José Ricardo Soares de; Sacramento,Luis Vitor Silva do; Santos,André Gonzaga dos; Leonardi,Gislaine Ricci; Chorilli,Marlus. |
| ABSTRACT This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Liquid crystals/evaluation/physical-chemical stability; Microemulsions/evaluation; Surfactant-based system; Organic cocoa extract; Skin bioadhesion. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300609 |
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