|
|
|
|
|
| Vasconcelos,Janaina Mota de; Móia,Lizomar de Jesus Maués Pereira; Amaral,Ivanete do Socorro Abraçado; Miranda,Esther Castello Branco Mello; CicaliseTakeshita,Louise Yukari; Oliveira,Layanna Freitas de; Mendes,Lilian de Araújo Melo; Sastre,Danuta; Tamegão-Lopes,Bruna Pedroso; Pedroza,Larysse Santa Rosa de Aquino; Santos,Sidney Emanuel Batista dos; Soares,Manoel do Carmo Pereira; Araújo,Marialva Tereza Ferreira de; Bandeira,Camila Lucas; Silva,Adriana Maria Paixão de Sousa da; Medeiros,Zilene Lameira de; Sena,Leonardo; Demachki,Samia; Santos,Eduardo José Melo dos. |
| Soroprevalence for Hepatitis C virus is reported as 2.12% in Northern Brazil, with about 50% of the patients exhibiting a sustained virological response (SVR). Aiming to associate polymorphisms in Killer Cell Immunoglobulin-like Receptors (KIR) with chronic hepatitis C and therapy responses we investigated 125 chronic patients and 345 controls. Additionally, 48 ancestry markers were genotyped to control for population stratification. The frequency of the KIR2DL2 and KIR2DL2+HLA-C Asp80 gene and ligand was higher in chronic infected patients than in controls (p < 0.0009, OR = 3.4; p = 0.001, OR = 3.45). In fact, KIR2DL3 is a weaker inhibitor of NK activity than KIR2DL2, which could explain the association of KIR2DL2 with chronic infection. Moreover,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HCV; KIR; HLA-C; Hepatitis C; KIR2DL2. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100004 |
| |
|
|
| Mousinho-Ribeiro,Rita de Cassia; Pante-de-Sousa,Gabriella; Santos,Eduardo José Melo dos; Guerreiro,João Farias. |
| The distribution of b-globin gene haplotypes was studied in 209 Amerindians from eight tribes of the Brazilian Amazon: Asurini from Xingú, Awá-Guajá, Parakanã, Urubú-Kaapór, Zoé, Kayapó (Xikrin from the Bacajá village), Katuena, and Tiriyó. Nine different haplotypes were found, two of which (n. 11 and 13) had not been previously identified in Brazilian indigenous populations. Haplotype 2 (+ - - - -) was the most common in all groups studied, with frequencies varying from 70% to 100%, followed by haplotype 6 (- + + - +), with frequencies between 7% and 18%. The frequency distribution of the b-globin gene haplotypes in the eighteen Brazilian Amerindian populations studied to date is characterized by a reduced number of haplotypes (average of 3.5) and low... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA polymorphisms; Brazilian Amerindians; Genetic diversity. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300002 |
| |
|
|
| Pante-de-Sousa,Gabriella; Mousinho-Ribeiro,Rita de Cassia; Santos,Eduardo José Melo dos; Zago,Marco Antonio; Guerreiro,João Farias. |
| We analyzed DNA polymorphisms in the <FONT FACE="Symbol">b</font>-globin gene cluster of 30 sickle cell anemia patients from Belém, the capital city of the State of Pará, in order to investigate the origin of the <FONT FACE="Symbol">b</font>S mutation. Sixty-seven percent of the <FONT FACE="Symbol">b</font>S chromosomes were Bantu type, 30% were Benin type, and 3% were Senegal type. The origin of the <FONT FACE="Symbol">b</font>S mutation in this population, estimated on the basis of <FONT FACE="Symbol">b</font>S-linked haplotypes, contradicts the historical records of direct slave trade from Africa to the northern region of Brazil. Historical records indicate a lower percentage of people from... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000400001 |
| |
|
|
| Guerreiro,João Farias; Ribeiro-dos-Santos,Ândrea Kely Campos; Santos,Eduardo José Melo dos; Vallinoto,Antonio Carlos Rosário; Cayres-Vallinoto,Izaura Maria Vieira; Aguiar,Gilberto Ferreira de Souza; Santos,Sidney Emanuel Batista dos. |
| The Amazon region of Brazil includes communities founded by escaped slaves, some of which still remain relatively isolated. We studied two such Afro-Brazilian communities (Pacoval and Curiau), in the rural area of Alenquer, Pará, and in the metropolitan region of Macapá, Amapá, respectively. Among 12 blood loci, alleles considered as markers of African ancestry, such as HBB*S, HBB*C, TF*D1, HP*2M, ABO*B, RH*D-, and CA2*2 were found at frequencies that are expected for populations with a predominantly African origin. Estimates of interethnic admixture indicated that the degree of the African component in Curiau (74%) is higher than that of Pacoval (44%); an Amerindian contribution was not detected in Curiau. Estimated values of African ancestry fit well... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000200004 |
| |
|
|
|
