|
|
|
|
|
| Arantes,Paula de Oliveira; Santos,Quesia Nery dos; Freitas,Zaida Maria Faria de; Pyrrho,Alexandre dos Santos; Cerqueira-Coutinho,Cristal; Villa,Ana Lucia Vazquez; Santos,Elisabete Pereira dos; Ricci-Júnior,Eduardo. |
| ABSTRACT This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index (IP<0.1), spherical shape without aggregation, pH compatible with typical skin levels and stability evaluated by seven months. In the permeation studies, a classical formulation based in an oil/water cream containing nifedipine was used for comparison with NE. Nanoemulsion promoted and improved the retention of nifedipine in the epidermis and dermis in relation to classical formulation. This promoting effect is related to the nanometric size of the droplets of the NE (20 nm), which give him a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Topical nifedipine/cutaneous permeation; Nanoemulsion/characterization; Stability; Cutaneous permeation/study; Healing of wounds. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200628 |
| |
|
|
| Teixeira,Jessica; Freitas,Zaida Maria Farias de; Monteiro,Mariana Sato de Souza Bustamante; Vermelho,Alane Beatriz; Ricci Junior,Eduardo; Santos,Elisabete Pereira dos. |
| This work deals with development and evaluation of MFQ protective formulation, which contains two organic filters, namely: octyl-p-methoxycinnamate (OMC) and benzophenone-3 (BP-3); a photostabilizing agent called ethylhexylmethoxycrylene (EHMCR) and keratin particles. The MFQ formulation was evaluated in order to measure its pH, spin-spin lattice relaxation time (T2H), occlusivity factor, formulation efficacy, photostability and skin permeation, as well as keratin particle properties. Keratin particle size increased when incorporated to formulation, however, it did not affect pH. The MFQ formulation was found to be photostable and photoprotective, as evidenced by sunlight photostability test, sun protection factor (SPF), UVA/UVB ratio and critical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sunscreen; Keratin; Octylmethoxycinnamate; Benzophenone-3; Ethylhexylmethoxycrylene. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100597 |
| |
|
|
| Gonçalves,Felipe da Silva; Giovanini,Iris Ramos Torres; Cerqueira,Cristal; Ricci Junior,Eduardo; Freitas,Zaida Maria Faria de; Santos,Elisabete Pereira dos. |
| The aim of this study was to develop and evaluate a corrective and photoprotective makeup for patients with dyschromias. An emulsion was prepared and pigment mixtures were incorporated in the formulation, producing five shades of corrective makeup: BEIGE (I, II, III), BRONZE and TAN. The sun protection factor (SPF) and UVA/UVB ratio of the corrective makeup were determined using spectrophotometry with a Labsphere® analyser. The spreadability, occlusivity, stability, and photostability of the photoprotective formulations were also evaluated. For all formulations there was no statistical difference among them (p > 0.05) in terms of spreadability, occlusivity and SPF. They were considered to be photostable under solar radiation, with variations in SPF... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Corrective makeup; Dyschromias; Sunscreens; Emulsions cosmetics. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400613 |
| |
|
|
| Pinto,Isadora Cabral; Cerqueira-Coutinho,Cristal; Freitas,Zaida Maria Faria de; Santos,Elisabete Pereira dos; Carmo,Flávia Almada do; Ricci Junior,Eduardo. |
| ABSTRACT Diseases caused by insects are frequent in poor countries, leading to epidemic scenarios in urban areas; e.g., Dengue, Zika and Chikungunya. For this reason, the development of a safe and efficient topical formulation is essential. Ethyl butylacetylaminopropionate (EB) is a mosquito repellent developed by Merck, which is used in products for adults, children and especially babies, due to its low allergenic potential. The aim of this work was to validate an analytical methodology to quantify EB in a new poloxamer-based formulation by high-performance liquid chromatography (HPLC). The quantification methodology was performed at 40 ºC using a Kromasil reverse-phase column (C18), with the dimensions of 250 x 4.6 mm. The mobile phase was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ethyl butylacetylaminopropionate (EB)/quantification; Ethyl butylacetylaminopropionate (EB)/topical formulations; Analytical method; Validation; Repellents; Prophylaxis; High Performance Liquid Chromatography.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200613 |
| |
|
| |
|
|
| Silva,Márcio Robert Mattos da; Dysars,Letícia Pereira; Santos,Elisabete Pereira dos; Ricci Júnior,Eduardo. |
| At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Extemporaneous oral liquid; Stability; Hospital pharmacy. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100703 |
| |
|
|
| Deccache,Daniela Soares; Santos,Elisabete Pereira dos; Cabral,Lúcio Mendes; Rodrigues,Carlos Rangel; Sousa,Valéria Pereira de. |
| DMAE glycolate (DG) and sunscreens have been used associated in anti-aging dermocosmetic formulations. Despite extensive use of these substances, methods for quantification of DG as raw material and in cosmetic formulations, especially when associated, are not described in the literature. RP-HPLC and non-aqueous titration methods, with determination potentiometric end-point (PT), were developed and validated for rapid assay of DG as raw material and in a topic emulsion in association with sunscreens. Both methods are simple, selective, linear, accurate and precise. The PT method was chosen for stability study of DG in the formulation developed. The proposed formulation presented good stability performance as regards aspect, pH, apparent viscosity, and SPF,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DMAE glycolate; Anti-aging dermocosmetic formulations/quantitative analysis; High Performance Liquid Chromatography-RP/quantitative analysis; Non-aqueous potentiometric titration/quantitative analysis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400012 |
| |
|
|
|
