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Polymeric micelles containing resveratrol: development, characterization, cytotoxicity on tumor cells and antimicrobial activity BJPS
Almeida,Tamires Cunha; Seibert,Janaina Brandão; Almeida,Sávio Henrique de Souza; Amparo,Tatiane Roquete; Teixeira,Luiz Fernando de Medeiros; Barichello,Jose Mario; Postacchini,Bruna Bueno; Santos,Orlando David Henrique dos; Silva,Glenda Nicioli da.
Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antimicrobial activity; Cytotoxic activity; F127®; Polymeric micelles; Resveratrol.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100567
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Antibacterial substances from leaves of Protium spruceanum (Burseraceae): in vitro and in silico evaluation BJPS
Amparo,Tatiane Roquete; Rodrigues,Ivanildes Vasconcelos; Seibert,Janaína Brandão; Almeida,Tamires Cunha; Cabral,Vivette Appolinário Rodrigues; Vieira,Paula Melo de Abreu; Brandão,Geraldo Célio; Oliveira,Mauro Lúcio Gonçalves de; Silva,Glenda Nicioli da; Santos,Orlando David Henrique dos; Vieira Filho,Sidney Augusto; Teixeira,Luiz Fernando Medeiros; Souza,Gustavo Henrique Bianco de.
Due to the increase of bacterial resistance, the search for new antibiotics is necessary and the medicinal plants represent its most important source. The aim of this study was to evaluate the antibacterial property of extract and fractions from Protium spruceanum leaves, against pathogenic bacteria. By means of diffusion and microdilution assays, the crude extract was active against the nine bacteria tested being the hydromethanolic fraction the most active. During phytochemical procedures, procyanidin (1) and catechin (2) were identified as the main antibacterial constituents of this fraction. In silico results obtained using PASSonline tool indicated 1 and 2 as having good potential to interact with different targets of currently used antibiotics. These...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Protium spruceanum; Burseraceae; Procyanidin; Catechin; Antibacterial activity.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100623
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