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| Onishi, Kenji; Sarumoh, Bolu Muhammad; Hagiwara, Daisuke; Watanabe, Akira; Kamei, Katsuhiko; Toyotome, Takahito. |
| Azole-resistant strains of Aspergillus fumigatus containing a tandem repeat in the cyp51A promoter and amino acid substitution(s) have been isolated in the environment worldwide; however, this type of resistant strain had never been isolated from the environment in Japan. Our previous study indicated that an azole-resistant A. fumigatus strain OKH50 containing a 34-bp tandem repeat in cyp51A promoter with L98H substitution in Cyp51A was isolated from a patient in Obihiro of Hokkaido, Japan. In this study, we collected azole-resistant Aspergillus spp. by air sampling from the environment in Japan. One Aspergillus-like colony was isolated from one of 10 sampling sites surveyed. The strain Env1 was confirmed as A. fumigatus by nucleotide sequencing and... |
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Palavras-chave: Aspergillus fumigatus; Azole; Cyp51A; TR34/L98H. |
| Ano: 2017 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4565 |
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