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	Provedor de dados BJPS (1) Autor Andreazza,Itamar Francisco (1) Murakami,Fábio Seigi (1) Sato,Mayumi Elisa Otsuka (1) Tondo Filho,Volnei Jose (1) Palavra-chave Enteric release mini-tablets/development (1) Enteric release mini-tablets/evaluation (1) Multiparticulate system/modified release (1) Omeprazole/dissolution (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole BJPS Tondo Filho,Volnei Jose; Andreazza,Itamar Francisco; Sato,Mayumi Elisa Otsuka; Murakami,Fábio Seigi. The main aim of this study was to develop a multiparticulate system containing mini-tablets of omeprazole formulated with an enteric polymer with pH-dependent solubility. Pre-formulation studies showed good flow and compaction capacity, leading to the production ofhigh quality mini-tablets. The mini-tablets were coated in a fluidized bed with hydroxypropylmethylcellulose /Eudragit(r) L30D55 and packed into hard gelatin capsules. The dissolution profile showed gastro-resistance and zero-order kinetics. The dissolution profile for the formulation containing lactose as the diluent and coated with 12% (tablet weight gain) of polymer was similar to that ofthe reference drug. Tipo: Info:eu-repo/semantics/article Palavras-chave: Multiparticulate system/modified release; Enteric release mini-tablets/development; Enteric release mini-tablets/evaluation; Omeprazole/dissolution. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300505 Registros recuperados: 1 Primeira ... 1 ... Última

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