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	Provedor de dados Genet. Mol. Biol. (1) Autor Deissler,Helmut (1) Herman,Sandra (1) Sauer,Georg (1) Scholz,Claus-Jürgen (1) Wolfahrt,Sonja (1) Palavra-chave CD9 (1) Membrane topology (1) Splice variant (1) Tetraspanin (1) Transcript (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Identification of alternative transcripts of rat CD9 expressed by tumorigenic neural cell lines and in normal tissues Genet. Mol. Biol. Wolfahrt,Sonja; Herman,Sandra; Scholz,Claus-Jürgen; Sauer,Georg; Deissler,Helmut. CD9 is the best-studied member of the tetraspanin family of transmembrane proteins. It is involved in various fundamental cellular processes and its altered expression is a characteristic of malignant cells of different origins. Despite numerous investigations confirming its fundamental role, the heterogeneity of CD9 or other tetraspanin proteins was considered only to be caused by posttranslational modification, rather than alternative splicing. Here we describe the first identification of CD9 transcript variants expressed by cell lines derived from fetal rat brain cells. Variant mRNA-B lacks a potential translation initiation codon in the alternative exon 1 and seems to be characteristic of the tumorigenic BT cell lines. In contrast, variant mRNA-C can... Tipo: Info:eu-repo/semantics/article Palavras-chave: CD9; Tetraspanin; Transcript; Splice variant; Membrane topology. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000200019 Registros recuperados: 1 Primeira ... 1 ... Última

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