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| Schwanke,C.H.A.; Bittencourt,L.; Noronha,J.A.P.; Augustin,S.A.J.; Jung,I.E.; Cruz,I.B.M.. |
| The regulation of bladder function is influenced by central serotonergic modulation. Several genetic polymorphisms related to serotonin control have been described in the literature. T102C polymorphism of the serotonin receptor 2A gene (5-HT2A) has been shown to be associated with certain diseases such as non-fatal acute myocardial infarction, essential hypertension, and alcoholism. In the present study, we examined the association between 5-HT2A gene polymorphism and urinary incontinence in the elderly. A case-control study was performed in 298 elderly community dwellers enrolled in the Gravataí-GENESIS Project, Brazil, which studies gene-environmental interactions in aging and age-related diseases. Clinical, physical, biochemical, and molecular analyses... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: T102C polymorphism of the serotonin receptor 2A gene; 5-HT2A gene polymorphism; Urinary incontinence; Elderly patients. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000003 |
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| Jobim,P.F.C.; Prado-Lima,P.A.S.; Schwanke,C.H.A.; Giugliani,R.; Cruz,I.B.M.. |
| Epidemiological investigations suggest that T102C polymorphism of gene 5-HT2A may be associated with mean life span because diseases and behaviors related to this polymorphism, such as schizophrenia, suicide, aggression, and addiction, may potentially shorten mean life span. A sample of 687 individuals without previous neuropsychiatric disease was genotyped and separated into 3 groups according to their gender and age: 14-45 years old, 46-64 years old and 65-100 years old. Molecular genotyping was performed using the technique of polymerase chain reaction followed by restriction fragment length polymorphism using HpaII restriction enzyme. 5-HT2A genotype frequencies were: TT = 21.5% (148), CC = 16.6% (114) and TC = 61.9% (425) and allele frequencies were T... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mean life span; Serotonin; Receptor 2A; T102C polymorphism. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001100012 |
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