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| Schwarz,Aline; Hosomi,Rosana Zoriki; Flório,Jorge Camilo; Bernardi,Maria Martha; Górniak,Silvana Lima; Spinosa,Helenice Souza. |
| The present study evaluated the central monoamine levels of male and female adult rat offspring exposed orally by gavage to 0.0, 0.7, 3.0 and 15.0 mg/kg I. carnea aqueous extract daily, from gestation day (GD) 5 to GD 21. Several alterations in the monoamine activity systems were observed. However, the major differences were noted between the 0.0 mg/kg and the no gavage control groups, showing that alterations showing that alterations were not due to the alterations to the aqueous extract. The control data showed that gavage and handling of dams were stressful enough to produce a significant decline in 3,4-dihydroxyphenylacetic acid (DOPAC) and an increase in vanilmandelic acid (VMA), indicating decreased dopamine (DA) and enhanced norepinephrine (NE)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ipomoea carnea; Neurotransmitter; Perinate; Rats; Stress. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000300009 |
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| Queiroz,Fernando Márlisson de; Matias,Kayo Wanderson de Oliveira; Cunha,Mylena Mylana Freire da; Schwarz,Aline. |
| Phyllanthus niruri L. (Euphorbiaceae), known as "quebra-pedra" (Portuguese for "stonebreaker"), is an herb used for kidney disorders. In light of its frequent use by the population, the present study aimed to investigate the genotoxic, antigenotoxic and cytotoxic activities of a standardized P. niruri extract in bone marrow rats. Three groups of 12 animals were treated daily by gavage over a period of 30 days, with 50, 150 or 250 mg/kg of P. niruri extract aqueous solution. The control group (n = 12) received tap water. At the end of treatment (day 31), groups were divided into two minor subgroups (n=6/group) and received cyclophosphamide (50 mg/kg, i.p.) or saline 0.9% (i.p.). After 24 hours, we evaluated the frequency of micronucleated polychromatic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Phyllanthus niruri L./genotoxicity; Phyllanthus niruri L./toxicological analysis; Phyllanthus niruri L./experimental study; Medicinal plantas/evaluation. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100015 |
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