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| Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Azoubel,Reinaldo; Sala,Miguel A; Mattos,Maria G. C; Hallak Regalo,Simone Cecílio. |
| Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency. This work had the goal to study the lingual mucosa, under histopathological and morphometric standpoints, in rat fetuses which were given an intraperitonial injection, consisting of a unique dose of phenytoin (70 milligrams/kilogram of their weight). Being that, we included the examined material in paraffin, 6 micrometers thick, and... |
| Tipo: Journal article |
Palavras-chave: Phenytoin; Lingual mucosa; Rat; Morphometry. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009 |
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| Ribas,Paulo; Lopes,Ruberval A.; Sala,Miguel A.; Ribas,Lucia M.R.; de Mattos,Maria da Glória C.; Semprini,Marisa; Watanabe,Ii-Sei; Regalo,Simone C.H.. |
| Cadmium in the air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cadmium affects placental functions, can cross the placental barrier and directly disturbs fetal development. It is also excreted into milk. The organism is particularly susceptible to cadmium exposure at perinatal period. The effect on rat maxillary molar junctional epithelium a continuous exposure to drinking water containing low level of cadmium during lactation was studied. Female rats received drinking water ad libitum containing 300 mg/l CdCl2 throughout the whole lactation. Control animals received a similar volume of water without cadmium. Lactent rats (21 day-old) were killed by lethal dose of... |
| Tipo: Journal article |
Palavras-chave: Oral mucosae; Junctional epithelium; Cadmium; Lactation; Morphometry; Stereology. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400003 |
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| Carrara Moreti,Dora Lúcia; Lopes,Ruberval Armando; Vinha,Dionisio; Sala,Miguel Angel; Semprini,Marisa; Friedrichi,Christiane. |
| El objetivo del presente trabajo fue caracterizar morfológica, morfométrica y estereológicamente las alteraciones causadas por la administración de albendazol en ratas preñadas en el hígado de los fetos. Fueron usadas ratas Wistar, que recibieron entre los días 9 y 11 de la preñez, una dosis diaria de 5 mg/kg de peso de albendazol. Las ratas control recibieron volumen semejante de suero fisiológico en los mismos días. Al 20 día, las ratas fueron sacrificadas por inhalación de éter, siendo retirados los fetos e inmediatamente fijados en alfac por 24 h. Los fetos, úteros y placentas, luego de fijados, fueron secados en papel de filtro y pesados en balanza de precisión, siendo medidos los cordones umbilicales con nonio. Los cuerpos de los fetos fueron... |
| Tipo: Journal article |
Palavras-chave: Hígado; Feto; Rata; Albendazol; Morfometría. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200003 |
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| Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Sala,Miguel A; Mattos,Maria G. C. |
| Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Rat; Meckel's cartilage; Lingual musculature; Submandibular gland. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006 |
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