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| Baby,André Rolim; Lacerda,Áurea Cristina Lemos; Sarruf,Fernanda Daud; Pinto,Claudinéia Aparecida Sales de Oliveira; Consiglieri,Vladi Olga; Serra,Cristina Helena dos Reis; Velasco,Maria Valéria Robles; Kawano,Yoshio; Kaneko,Telma Mary. |
| Recently, there has been an interest in the use of shed snake skin as alternative model biomembrane for human stratum corneum. This research work presented as objective the qualitative characterization of alternative model biomembranes from Bothrops jararaca and Spilotis pullatus by FT-Raman, PAS-FTIR and DSC. The employed biophysical techniques permitted the characterization of the biomembranes from shed snake skin of B. jararaca and S. pullatus by the identification of vibrational frequencies and endothermic transitions that are similar to those of the human stratum corneum. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biomembrane/alternative models; Bothrops jararaca/skin; Bothrops jararaca/qualitative characterization; Spilotis pullatus/skin; Spilotis pullatus/qualitative characterization; Human stratum corneum/similars. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300006 |
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| Kano,Eunice Kazue; Koono,Eunice Emiko Mori; Schramm,Simone Grigoleto; Serra,Cristina Helena dos Reis; Abib Junior,Eduardo; Pereira,Renata; Freitas,Márcia Sayuri Takamatsu; Iecco,Maria Cristina; Porta,Valentina. |
| Average bioequivalence of two 500 mg levofloxacin formulations available in Brazil, Tavanic(c) (Sanofi-Aventis Farmacêutica Ltda, Brazil, reference product) and Levaquin(c) (Janssen-Cilag Farmacêutica Ltda, Brazil, test product) was evaluated by means of a randomized, open-label, 2-way crossover study performed in 26 healthy Brazilian volunteers under fasting conditions. A single dose of 500 mg levofloxacin tablets was orally administered, and blood samples were collected over a period of 48 hours. Levofloxacin plasmatic concentrations were determined using a validated HPLC method. Pharmacokinetic parameters Cmax, Tmax, Kel, T1/2el, AUC0-t and AUC0-inf were calculated using noncompartmental analysis. Bioequivalence was determined by calculating 90%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Levofloxacin/bioequivalence; Pharmacokinetics; High-performance liquid chromatography/qualitative analysis; Tavanic(c)/bioequivalence; Levaquin(c)/bioequivalence. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100203 |
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