Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJPS (3) Autor Sezer,Ali Demir (3) Gürten,Berna (2) Malta,Seyda (2) Yenigül,Elçin (2) Altan,Cem (1) Ayata,Neşe (1) Bucak,Seyda (1) Turanlı,Eda Tahir (1) Mais... Palavra-chave Anticancer (1) Calorimetry. (1) Cell culture (1) Chitosan (1) Chromatography (1) Cyclodextrin (1) Cyclodextrins (1) Drug delivery (1) Magnetic nanoparticles (1) Magnetite (1) Monoclonal antibody (1) Ranibizumab (1) Targeting (1) Temozolomide (1) Temozolomide/solubility/complexation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (2) 2018 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Preparation and in vitro characterization of monoclonal antibody ranibizumab conjugated magnetic nanoparticles for ocular drug delivery BJPS Ayata,Neşe; Sezer,Ali Demir; Bucak,Seyda; Turanlı,Eda Tahir. Gold coated magnetite nanoparticles were prepared and coated with ranibizumab as an ocular drug delivery system. The surface morphologies of the nanoparticles were determined by Scanning Electron Microscopy (SEM). The size and surface charge were determined by using the dynamic light scattering (DLS) technique. Crystallographic properties of the gold coated Fe3O4 nanoparticles were recorded on X-ray diffractometer (XRD) the XRD pattern of nanoparticlees were shown to have uniqe Fe3O4 and gold peaks. Conjugation of ranibizumab onto nanoparticles was achieved using the physical adsorption method. The amount of ranibizumab on the surface of the nanoparticles was determined by thermogravimetric analysis (TGA). In the in vitro release studies performed using UV... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ranibizumab; Monoclonal antibody; Drug delivery; Magnetic nanoparticles; Cell culture. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100587 Targeting of temozolomide using magnetic nanobeads: an in vitro study BJPS Gürten,Berna; Yenigül,Elçin; Sezer,Ali Demir; Altan,Cem; Malta,Seyda. Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of b-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Temozolomide; Magnetite; Cyclodextrin; Chitosan; Targeting; Anticancer. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100574 Complexation and enhancement of temozolomide solubility with cyclodextrins BJPS Gürten,Berna; Yenigül,Elçin; Sezer,Ali Demir; Malta,Seyda. ABSTRACT Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide and the different types of cyclodextrins (CDs) to enhance its solubility. In this study, three different cyclodextrins (β -CD, hydroxyl-β-CD and γ-CD) were used, and changes in solubility was measured by UV-Vis Spectroscopy and HPLC. Morphological changes upon complexation were shown by the Scanning Electron Microscope (SEM), and weight loss profiles with respect to temperatures which were unique to the compounds were shown by Thermogravimetric Analysis.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Temozolomide/solubility/complexation; Cyclodextrins; Chromatography; Calorimetry.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200606 Registros recuperados: 3 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco