|
|
|
|
|
| Yousaf,Abid Mehmood; Malik,Usman Rashid; Shahzad,Yasser; Hussain,Talib; Khan,Ikram Ullah; Din,Fakhar Ud; Mahmood,Tariq; Ahsan,Hafiz Muhammad; Syed,Ahmed Shah; Akram,Muhammad Rouf. |
| Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the electrospraying technique. The influence of the hydrophilic carriers on solubility and dissolution was explored. The solid-state characterization was carried out by particle-size analysis, PXRD, DSC, FTIR and SEM. All of the formulations demonstrated better solubility and dissolution than did silymarin plain powder. Both the SDS and PVP had positive effects on solubility and dissolution of silymarin in the aqueous media. An increased solubility was attained as the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Silymarin; Electrospraying; PVP-nanocontainers; Aqueous solubility; Dissolution. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100612 |
| |
|
|
| Sohail,Kashif; Khan,Ikram Ullah; Shahzad,Yasser; Hussain,Talib; Ranjha,Nazar Muhammad. |
| In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drugs/release; Hydrogels/pH sensitive; Polyvinylpyrrolidone-acrilic acid/hidrogels; Tramadol hydrochloride; Methylene bisacrylamide. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100018 |
| |
|
| |
|
|
|
