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	Provedor de dados BJID (1) BJMBR (1) BJM (1) Autor Shi,Ming (3) Zhang,Jing (2) Zhang,Yong (2) Cao,Chengsong (1) Liu,Wei (1) Liu,Yong (1) Wang,Qing (1) Wang,Qun (1) Xing,Lu (1) Xu,Wei-Jia (1) Zhao,Jing (1) Zheng,Junnian (1) Mais... Palavra-chave Hepatitis B virus (2) Affymetrix Gene Chip (1) Alanine transaminase (1) CHPF (1) Genotype (1) Invasion (1) Lung cancer (1) Mutation (1) Pre-S1 (1) Precore mutation (1) Proliferation (1) TCGA (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2012 (1) 2009 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels BJID Shi,Ming; Zhang,Yong; Zhang,Jing; Liu,Wei; Xing,Lu. Hepatitis B virus (HBV) genotype and precore and basal core promoter (BCP) mutants in the patients with persistently normal alanine aminotransferase (ALT) and low serum HBV-DNA levels are unclear. The aim of this study was to determine HBV genotypes, precore and BCP mutations, and their association with chronic hepatitis and liver fibrosis in HBV-infected patients with persistently normal ALT, and low serum HBV-DNA levels in northeast China. Patients (n = 89) with normal ALT and serum HBV-DNA levels below 20000 IU/mL but detectable with real-time PCR were included in this study. HBV genotypes were determined by real-time PCR. The precore and BCP mutations were detected by sequencing. All the patients had biopsy results. Of the 89 patients, 11 (12.4%) were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B virus; Genotype; Mutation; Alanine transaminase. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100009 Expression of CHPF modulates cell proliferation and invasion in lung cancer BJMBR Cao,Chengsong; Liu,Yong; Wang,Qun; Zhao,Jing; Shi,Ming; Zheng,Junnian. Lung cancer is the most common malignancy worldwide and is characterized by rapid progression, aggressive behavior, frequent recurrence, and poor prognosis. The TCGA database indicates that chondroitin polymerizing factor (CHPF) is overexpressed in human lung cancer tissues compared with normal tissues and this overexpression corresponds to shorter overall survival in lung cancer patients. In this study, to investigate the function of CHPF in lung cancer, lentiviral vectors expressing CHPF shRNA were stably transduced into A549 and H1299 cells. Compared to shCtrl cells, CHPF knockdown cells had significantly reduced proliferation. Furthermore, the silencing of CHPF in A549 and H1299 cells resulted in apoptotic induction, which led to decreased colony... Tipo: Info:eu-repo/semantics/article Palavras-chave: CHPF; Lung cancer; Proliferation; Invasion; TCGA; Affymetrix Gene Chip. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500610 Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen BJM Zhang,Jing; Xu,Wei-Jia; Wang,Qing; Zhang,Yong; Shi,Ming. This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients. Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B virus; Precore mutation; Pre-S1. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400031 Registros recuperados: 3 Primeira ... 1 ... Última

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