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Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta BJMBR
Felipe,S.A.; Rodrigues,E.S.; Martin,R.P.; Paiva,A.C.M.; Pesquero,J.B.; Shimuta,S.I..
Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, no information is available about the agonists bradykinin (BK) and DesArg9BK (DBK). Our aim was to determine the potential expression of kinin B1 and B2 receptors in the abdominal mouse aorta isolated from C57BL/6 mice. Contraction and relaxation responses to BK and DBK were investigated using isometric recordings. The kinins were unable to induce relaxation but concentration-contraction response curves were obtained by applying increasing concentrations of the agonists BK and DBK. These effects were blocked by the antagonists Icatibant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Kinin B1 and B2 receptors; Bradykinin; DesArg9bradykinin; Indomethacin; L-NAME.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500007
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