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| Ali,Tariq; Shoaib,Muhammad Harris; Yousuf,Rabia Ismail; Jabeen,Sabahat; Muhammad,Iyad Naeem; Tariq,Asfia. |
| The aim of the present study was to develop tizanidine controlled release matrix. Formulations were designed using central composite method with the help of design expert version 7.0 software. Avicel pH 101 in the range of 14-50% was used as a filler, while HPMC K4M and K100M in the range of 25-55%, Ethylcellulose 10 ST and 10FP in the range of 15 - 45% and Kollidon SR in the range of 25-60% were used as controlled release agents in designing different formulations. Various physical parameters including powder flow for blends and weight variation, thickness, hardness, friability, disintegration time and in-vitro release were tested for tablets. Assay of tablets were also performed as specified in USP 35 NF 32. Physical parameters of both powder blend and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tizanidine/controlled release; Hydroxypropyl methylcellulose/controlled release agent; Ethylcellulose/controlled release agent; Kollidon SR/controlled release agent; Tablets/controlled release. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400799 |
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| Bushra,Rabia; Shoaib,Muhammad Harris; Aslam,Nousheen; Mehmood,Zafar Alam; Hashmat,Durriya. |
| Ibuprofen is a propionic acid derivative that belongs to the class NSAIDs. Major adverse reactions associated with Ibuprofen are related to GIT and include peptic and mucosal ulcers, dyspepsia, severe gastric pain and bleeding, that results in excessive treatment failure. The goal of this study was to develop enteric coated ibuprofen tablets in order to avoid gastric mucosal irritation, diffusion of drug across mucosal lining and to let active ingredient be absorbed easily in small intestine. The formulation was developed and manufactured through the direct compression process, the simplest, easiest and most economical method of manufacturing. Enteric coating was done using an Opadry white subcoating and an aqueous coating dispersion of Acryl-Eze. Enteric... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ibuprofen/adverse reactions; Tablets/enteric coating/aqueous dispersion system; Acryl-Eze. Opadry White; Superdisintegrant. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100011 |
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