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| Rufino,Marcos Natal; Cereda,Marney Pascoli; Barreto,Wanessa Teixeira Gomes; Silva,Alanderson Rodrigues da; Andrade,Gisele Braziliano de; Herrera,Heitor Miraglia. |
| ABSTRACT Cassava has been widely used for animal and human nutrition. It has also been demonstrated to have antineoplastic and anthelmintic properties. Toxicity due to cassava consumption has been reported in ruminants and laboratory animals; therefore, this study aimed to investigate the toxic effects of acetone cyanohydrin, a metabolite of linamarin that is present in cassava, in Wistar rats. Six groups of five animals each were used to evaluate the toxic effects of acetone cyanohydrin administered at 25 (G1), 50 (G2), 75 (G3), 100 (G4) and 125 (G5) µmol/kg as a single oral dose. The control group received acidified water (pH 3.5). The animals were monitored after administration of acetone cyanohydrin, and clinical symptoms were recorded. Serum enzyme... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurotoxic; Hepatotoxic; Cyanide; Acute intoxication. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542016000500577 |
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