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	Provedor de dados Genet. Mol. Biol. (4) BJM (1) Autor Silva,Ana Elizabete (5) Bizari,Lucimari (2) Bellini,Marilanda Ferreira (1) Colombo,Jucimara (1) Cury,Patrícia Maluf (1) César,Ana Cristina Gobbo (1) Duarte,Márcia Cristina (1) Liberatore,Paula Rahal (1) Payão,Spencer Luiz Marques (1) Rossit,Andréa Regina Baptista (1) Tajara,Eloiza H. (1) Tajara,Eloiza Helena (1) Varella-Garcia,Marileila (1) Mais... Palavra-chave Esophageal carcinoma (2) Adenocarcinoma (1) CCND1 (1) CGH (1) Carcinomas (1) Chromosome territories (1) DNA repair (1) Double minutes (1) Ethnic variability (1) FISH (1) Gastric cancer (1) Gastric lesions (1) Gene amplification (1) Gene expression (1) Genomic imbalances (1) HER-2/neu (1) Helicobacter pylori (1) Histological diagnosis (1) Molecular cytogenetics (1) Oncogenes (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Info:eu-repo/semantics/other (1) Ano 2010 (1) 2009 (1) 2006 (1) 2005 (2) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Comparison of histological and molecular diagnosis of Helicobacter pylori in benign lesions and gastric adenocarcinoma BJM César,Ana Cristina Gobbo; Cury,Patrícia Maluf; Payão,Spencer Luiz Marques; Liberatore,Paula Rahal; Silva,Ana Elizabete. Helicobacter pylori colonization is associated with chronic gastritis, peptic ulcers, intestinal metaplasia, adenocarcinoma and lymphoma of the stomach. The objective of this study was to compare the results of the routinely used histology with molecular diagnosis for the detection of H. pylori. Eighty samples from gastric lesions (chronic gastritis, atrophic gastritis, gastric ulcer, and intestinal metaplasia), 18 gastric adenocarcinoma and 10 normal mucosa H. pylori-negative (control) samples were obtained. All samples were examined histologically (hematoxylin-eosin and Giemsa staining), and PCR amplifications of the species-specific antigen gene (H3H4) and urease A gene segment (H5H6) of H. pylori were made, using the human gene CYP1A1 for DNA quality... Tipo: Info:eu-repo/semantics/article Palavras-chave: Helicobacter pylori; Gastric lesions; Adenocarcinoma; Histological diagnosis; PCR. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000100003 Peripheral position of CCND1 and HER-2/neu oncogenes within chromosome territories in esophageal and gastric cancers non-related to amplification and overexpression Genet. Mol. Biol. Bizari,Lucimari; Tajara,Eloiza Helena; Silva,Ana Elizabete. Interphase chromosomes have been shown to occupy discrete regions of the nucleus denominated chromosome territories (CTs), their active genes being preferentially positioned on the surfaces of these CTs, where they are accessible to transcriptional machinery. By means of FISH (Fluorescence in situ Hybridization), we analyzed the CCND1 and HER-2/neu gene positions within the CTs and their relationship with gene amplification and protein over-expression in esophageal and gastric cancers. The CCND1 and HER-2/Neu genes were more often positioned at the periphery (mean frequency of 60%-83%) of the CTs in tumor tissues of the esophagus and stomach. Moreover, this positioning revealed no association with either gene amplification or the protein over-expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: CCND1; HER-2/neu; Chromosome territories; Esophageal carcinoma; Gastric cancer. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200006 Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population Genet. Mol. Biol. Duarte,Márcia Cristina; Colombo,Jucimara; Rossit,Andréa Regina Baptista; Silva,Ana Elizabete. In several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry) for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium.... Tipo: Info:eu-repo/semantics/other Palavras-chave: DNA repair; XRCC1; XRCC3; Polymorphism; Ethnic variability. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300011 Gene amplification in carcinogenesis Genet. Mol. Biol. Bizari,Lucimari; Silva,Ana Elizabete; Tajara,Eloiza H.. Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to play a major role during embryonic development due to the fact that they are responsible for the programmed increase of gene expression. The etiology of gene amplification during carcinogenesis is not yet completely understood but can be considered a result of genetic instability. Gene amplification leads to an increase in protein expression and provides a selective advantage during cell growth. Oncogenes such as CCND1, c-MET, c-MYC, ERBB2, EGFR and MDM2 are amplified in human tumors and can be associated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene amplification; Gene expression; Oncogenes; Carcinomas; Double minutes. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100001 Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques Genet. Mol. Biol. Bellini,Marilanda Ferreira; Silva,Ana Elizabete; Varella-Garcia,Marileila. This review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2q, 3q, 5p, 6p, 7, 8q, 9q, 11q, 12p, 14q, 15q, 16, 17, 18p, 19q, 20q, 22q and X, with focal amplifications at 1q32, 2p16-22, 3q25-28, 5p13-15.3, 7p12-22, 7q21-22, 8q23-24.2, 9q34, 10q21, 11p11.2, 11q13, 13q32, 14q13-14, 14q21, 14q31-32, 15q22-26, 17p11.2, 18p11.2-11.3 and 20p11.2. Recurrent losses involved 3p, 4, 5q, 6q, 7q, 8p, 9, 10p, 12p, 13, 14p, 15p, 18, 19p, 20, 22, Xp and Y. Gains at 5p and 7q, and deletions at 4p, 9p, and 11q were significant prognostic... Tipo: Info:eu-repo/semantics/article Palavras-chave: CGH; Esophageal carcinoma; FISH; Genomic imbalances; Molecular cytogenetics. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200001 Registros recuperados: 5 Primeira ... 1 ... Última

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