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	Provedor de dados BABT (1) BJPS (1) Autor Silva,Marcos Antonio Segatto (2) Becker,Ana Cláudia (1) Benetti,Cibele Nabhan (1) Cardoso,Simone Gonçalves (1) Correa,Giane Márcia (1) Dellagnelo,Viviane Aparecida (1) Kuminek,Gislaine (1) Paulino,Niraldo (1) Pereira,Eduardo Manoel (1) Piazzon,Monika (1) Rodrigues,Patrik Oening (1) Scremin,Amarilis (1) Wagner,Theodoro Marcel (1) Mais... Palavra-chave Anti-inflammatory activity (1) Bioavailability (1) Deflazacort/quantitative determination (1) Dexamethasone acetate (1) High performance liquid chromatography/quantitative analysis (1) Medicines/quantitative analysis (1) Solubility (1) Spectrophotometry/quantitative analysis (1) Β-cyclodextrin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice BABT Rodrigues,Patrik Oening; Becker,Ana Cláudia; Dellagnelo,Viviane Aparecida; Benetti,Cibele Nabhan; Pereira,Eduardo Manoel; Wagner,Theodoro Marcel; Silva,Marcos Antonio Segatto. The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solubility; Dexamethasone acetate; Β-cyclodextrin; Bioavailability; Anti-inflammatory activity. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887 Spectrophotometric and HPLC determination of deflazacort in pharmaceutical dosage forms BJPS Scremin,Amarilis; Piazzon,Monika; Silva,Marcos Antonio Segatto; Kuminek,Gislaine; Correa,Giane Márcia; Paulino,Niraldo; Cardoso,Simone Gonçalves. Deflazacort (DFZ) is a glucocorticoid used as an anti-inflammatory and immunosuppressant drug. No official methods are available for DFZ determination in pharmaceutical formulations. The objective of this study was to develop, validate and compare spectrophotometric (UV and colorimetric) and high-performance liquid chromatography (HPLC) methods, for the quantitative determination of DFZ in tablets and oral suspension. For the UV method, ethanol was used as the solvent, with detection at 244 nm. The colorimetric method was based on the redox reaction with blue tetrazolium in alkaline medium, with detection at 524 nm. The method by HPLC was carried out using a C18 column, mobile phase consisting of acetonitrile:water (80:20, v/v) with a flow rate of 1.0 mL... Tipo: Info:eu-repo/semantics/article Palavras-chave: Deflazacort/quantitative determination; High performance liquid chromatography/quantitative analysis; Spectrophotometry/quantitative analysis; Medicines/quantitative analysis. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200015 Registros recuperados: 2 Primeira ... 1 ... Última

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