|
|
|
|
|
| Sousa,Eliane Leite de; Grangeiro,Ana Ruth Sampaio; Bastos,Isla Vanessa Gomes Alves; Rodrigues,Guilherme Carvalho Ribeiro; Silva,Maria Joselice e; Anjos,Falba Bernadete Ramos dos; Souza,Ivone Antonia de; Sousa,Cicero Ernandes Leite de. |
| Himatanthus drasticus, also known as janaguba, is used popularly in Brazil's Northeastern region in the treatment of cancer. However, no scientific reports are available. The present study is the first investigation on the antitumor activity of crude methanolic extract from Himatanthus drasticus leaves against Sarcoma 180 tumor and on its side effects including acute oral toxicity. The OECD 423 methodology was used to study acute oral toxicity, and the STOCK methodology to assess antitumor activity. The crude extract showed low toxicity at the tested doses (50, 300 and 2000 mg/kg) administered orally. The histopathological analyses demonstrated alterations in liver lung, spleen and kidney. It also showed activity against Sarcoma 180 tumor in male Swiss... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Himatanthus drasticus/antitumor activity; Himatanthus drasticus/acute oral toxicity; Janaguba/antitumor activity; Sarcoma 180/experimental study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200005 |
| |
|
|
|
