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Peginterferon plus ribavirin and sustained virological response rate in HCV-related advanced fibrosis: a real life study BJID
Silva,Giovanni Faria; Villela-Nogueira,Cristiane A.; Brandão Mello,Carlos Eduardo; Soares,Elza Cotrim; Coelho,Henrique Sergio M.; Abrão Ferreira,Paulo Roberto; Ruiz,Fernando José Goes.
Background:Tolerance and response to antiviral HCV treatment is poor in advanced fibrosis. The aim of this study was to assess SVR rate and its predictive factors in HCV advanced fibrosis patients treated in real life with full dose PEG-IFN plus RBV and to evaluate the adverse events related to treatment.Methods:A multicentric, retrospective study was conducted at six university hospitals. METAVIR F3 and F4 HCV monoinfected patients who were treated with PEG-IFN and RBV had their data analyzed. A stepwise logistic regression analysis was performed to identify the variables independently related to SVR. Adverse events were recorded during treatment.Results:308 patients were included, 75% genotype 1 and 23% genotype 3. METAVIR F3 was present in 39% and F4 in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Advanced fibrosis; Peginterferon; Ribavirin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100048
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Grading and staging chronic hepatitis C and its relation to genotypes and epidemiological factors in brazilian blood donors BJID
Silva,Giovanni Faria; Nishimura,Nancy F.; Coelho,Kunie Iabuki Rabello; Soares,Elza Cotrim.
Progression of chronic hepatitis C is known to be associated with some factors, but influence of HCV genotypes is still controversial. Association between HCV genotypes and other risk factors was examined to determine which factors are associated with progression of infection. One hundred consecutive anti-HCV positive volunteer blood donors were evaluated for several risk factors, examined for HCV genotypes, and submitted to hepatic biopsy and biochemical exams.HCV genotyping were carried out in 89 patients and hepatic biopsy in 78. Transmission routes were found to be illicit intravenous drug use (26%), Gluconergan® use in a non-safe manner (48%) and blood transfusion (15%). HCV genotype was 1 in 45%, 3 in 40%, and it was not associated with the stage of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Fibrosis; Risk factors.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200004
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