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| Souiden,Yosra; Mallouli,Hela; Meskhi,Salah; Chaabouni,Yassine; Rebai,Ahmed; Chéour,Foued; Mahdouani,Kacem. |
| BACKGROUND: Disturbance of the equilibrium between reactive oxygen species (ROS) and anti-oxidants (AOX) has been implicated in various diseases, including atherosclerosis, the most common pathologic process underlying coronary heart disease (CHD). Thus, the defense systems against ROS are critical protecting blood vessel walls against oxidative damage. In this study, we investigate whether Ala16Val MnSOD and Pro198Leu GPx polymorphisms are associated with CHD susceptibility and/or severity METHODS: Both polymorphisms were genotyped in a sample of 203 controls and 164 patients. CHD risk and severity, antioxidant status (enzymatic and/or non enzymatic) and biochemical parameters were assessed and analysed by genotype RESULTS: A significant association of... |
| Tipo: Journal article |
Palavras-chave: Genetic polymorphism; Coronary heart disease; SOD activity; GPx activity; Total antioxidant status; Atherosclerosis. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100022 |
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