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| Silva,J.S.; Aliberti,J.C.S.; Martins,G.A.; Souza,M.A.; Souto,J.T.; Pádua,M.A.. |
| Host resistance to Trypanosoma cruzi infection is dependent on both natural and acquired immune responses. During the early acute phase of infection in mice, natural killer (NK) cell-derived IFN-<FONT FACE="Symbol">g</font> is involved in controlling intracellular parasite replication, mainly through the induction of nitric oxide biosynthesis by activated macrophages. We have shown that IL-12, a powerful inducer of IFN-<FONT FACE="Symbol">g</font> production by NK cells, is synthesized soon after trypomastigote-macrophage interaction. The role of IL-12 in the control of T. cruzi infection in vivo was determined by treating infected mice with anti-IL-12 monoclonal antibody (mAb) and analyzing both parasitemia and mortality during the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: IL-12 Trypanosoma cruzi NK cells IFN-<; FONT FACE=Symbol>; G<; /font>; Nitric oxide. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100014 |
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