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| Souza,C.A.M.; de-Carvalho,R.R.; Kuriyama,S.N.; Araujo,I.B.; Rodrigues,R.P.; Vollmer,R.S.; E.N.,Alves; Paumgartten,F.J.R.. |
| The crude latex of Crown-of-Thorns (Euphorbia milii var. hislopii) is a potent plant molluscicide and a promising alternative to the synthetic molluscicides used in schistosomiasis control. The present study was undertaken to investigate the embryofeto-toxic potential of E. milii latex. The study is part of a comprehensive safety evaluation of this plant molluscicide. Lyophilized latex (0, 125, 250 and 500 mg/kg body weight) in corn oil was given by gavage to Wistar rats (N = 100) from days 6 to 15 of pregnancy and cesarean sections were performed on day 21 of pregnancy. The numbers of implantation sites, living and dead fetuses, resorptions and corpora lutea were recorded. Fetuses were weighed, examined for external malformations, and fixed for visceral... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Euphorbiaceae; Embryofeto-toxicity; Plant molluscicides; Euphorbia milii; Reproductive toxicity; Safety evaluation. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100011 |
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| Paumgartten,F.J.R.; De-Carvalho,R.R.; Souza,C.A.M.; Madi,K.; Chahoud,I.. |
| ß-Myrcene (MYR) is a monoterpene found in the oils of a variety of aromatic plants including lemongrass, verbena, hop, bay, and others. MYR and essential oils containing this terpenoid compound are used in cosmetics, household products, and as flavoring food additives. This study was undertaken to investigate the effects of MYR on fertility and general reproductive performance in the rat. MYR (0, 100, 300 and 500 mg/kg) in peanut oil was given by gavage to male Wistar rats (15 per dose group) for 91 days prior to mating and during the mating period, as well as to females (45 per dose group) continuously for 21 days before mating, during mating and pregnancy, and throughout the period of lactation up to postnatal day 21. On day 21 of pregnancy one-third of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SS-myrcene; Monoterpenes; Essential oils; Reproductive toxicity; Fertility; Embryofetal toxicity; Postnatal development. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700012 |
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