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	Provedor de dados BJPS (2) Autor Andreazza,Itamar Francisco (2) Goebel,Karin (2) Souza,Dayse Fernanda de (2) Murakami,Fábio Seigi (1) Sato,Mayumi Eliza Otsuka (1) Palavra-chave Diclofenac diethylamine/gel (1) Drugs/modified release (1) Generic semisolid drug products (1) In vitro release test (1) Mesalamine/evaluation (1) Mesalamine/modified release (1) Minitablets coated/evaluation (1) Minitablets coated/modified release (1) Polyethylene oxide/drugs coating (1) Synthetic membranes (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Development of enteric coated sustained release minitablets containing mesalamine BJPS Souza,Dayse Fernanda de; Goebel,Karin; Andreazza,Itamar Francisco. The aim of this study was to develop and evaluate a multiparticulate modified release system, composed of minitablets with a sustained release matrix system coated with a pH-dependent release polymer, using mesalamine as a model drug. Polyox® WSR 1105 was the polymer used in the matrix system and Eudragit® L30D55 was used as a pH-dependent polymer. The minitablets (with 20%, 30% or 40% Polyox® concentration) were prepared by dry granulation, which led to good quality minitablets. The developed minitablets were coated in a fluidized bed at 8% of the coating level. Dissolution studies were performed in media that simulated the gastrointestinal tract (pH 1.4, 6.0 and 7.2) and showed that formulations with higher Polyox® concentrations were capable of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesalamine/modified release; Mesalamine/evaluation; Minitablets coated/modified release; Minitablets coated/evaluation; Polyethylene oxide/drugs coating; Drugs/modified release. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300014 In vitro release of diclofenac diethylamine from gels: evaluation of generic semisolid drug products in Brazil BJPS Goebel,Karin; Sato,Mayumi Eliza Otsuka; Souza,Dayse Fernanda de; Murakami,Fábio Seigi; Andreazza,Itamar Francisco. In order for the pharmacological action of a topical dermal drug product to occur, the drug must first be released from the vehicle to be available to penetrate the skin layers and reach the site of action. Drug release is mainly dependent on the characteristics of the formulation. Currently, to register a generic or a similar drug product in Brazil performance testing of topical drug products for local action is not required. In this context, this aim of this study was to evaluate the in vitro release of commercial diclofenac diethylamine gel products available on the Brazilian pharmaceutical market, using the vertical diffusion cell method. Factors which may influence the test, such as the type of membrane used, and the effect of the formulation... Tipo: Info:eu-repo/semantics/article Palavras-chave: In vitro release test; Diclofenac diethylamine/gel; Synthetic membranes; Generic semisolid drug products. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200003 Registros recuperados: 2 Primeira ... 1 ... Última

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