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	Provedor de dados BJPS (1) Autor Gupta,Ankita (1) Rai,A. K. (1) Srivastava,Rishabh (1) Tiwari,Gaurav (1) Tiwari,Ruchi (1) Palavra-chave 5-Fluorouracil (1) Colorectal cancer/treatment (1) Drugs/delivery/colon targeting (1) HPMC capsules/enteric coating (1) Microsponges/formulation (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2015 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer BJPS Gupta,Ankita; Tiwari,Gaurav; Tiwari,Ruchi; Srivastava,Rishabh; Rai,A. K.. The work was aimed at developing novel enteric coated HPMC capsules (ECHC) plugged with 5 Florouracil (5-FU) loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content) on the dependent variables (Particle size, %EE & % CDR) were determined. The optimized microsponges (F4) were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100) and/ or Eudrgit S 100 (Ed-S 100) in different proportions. In vitro release... Tipo: Info:eu-repo/semantics/article Palavras-chave: 5-Fluorouracil; HPMC capsules/enteric coating; Microsponges/formulation; Drugs/delivery/colon targeting; Colorectal cancer/treatment. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300591 Registros recuperados: 1 Primeira ... 1 ... Última

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