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Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line BJMBR
de Araújo,E.S.S.; Vasques,L.R.; Stabellini,R.; Krepischi,A.C.V.; Pereira,L.V..
DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes. Disruption of the DNA methyltransferase genes DNMT1 and DNMT3B in the HCT116 cell line (DKO cells) leads to global DNA hypomethylation and biallelic expression of the imprinted gene IGF2 but does not lead to reactivation of XIST expression, suggesting thatXIST repression is due to a more stable epigenetic mark than imprinting. To test this hypothesis, we induced acute hypomethylation in HCT116 cells by 5-aza-2′-deoxycytidine (5-aza-CdR) treatment (HCT116-5-aza-CdR) and compared that to DKO cells, evaluating DNA methylation by microarray and monitoring the expression of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: XIST; Imprinted genes; DNA methylation; 5-aza-2′-deoxycytidine; Human cell line.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201029
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